In order to investigate the effects of titanium dioxide nanoparticles (nano-TiO2) on some quantitative and qualitative characteristics of strawberry cv. Sabrina, a factorial greenhouse experiment was conducted in a completely randomized design with three replications. The strawberry plants were sprayed with titanium dioxide nanoparticles (0, 6 and 12 mg L^-1) and under different deficient fertigation treatments (90, 110 and 130 ml). At the end of the experiment, traits such as leaf chlorophyll a and b, pH, TA, TSS, carotenoids, fresh and dry weight of aerial parts and roots, fruit weight, length and width and yield were evaluated. The results showed that the interaction effect of deficient fertigation and titanium dioxide nanoparticles treatments on fruit weight, fresh and dry weight of roots and aerial parts, chlorophyll a and yield was significant, so that the highest yield, fruit weight and fresh and dry weight of roots and aerial parts were observed in 130 ml of deficient fertigation and 12 mg L^-1 titanium dioxide nanoparticles treatments. Also, the main effects of deficient fertigation and titanium dioxide nanoparticles treatments were significant on fruit length and width, pH, TA, TSS, chlorophyll b and carotenoids traits. The highest length and width of fruits, pH, TSS and carotenoids were observed by separate using of 12 mg L^-1 titanium dioxide nanoparticles or 130 ml of deficient fertigation. In general, the obtained results of this study showed that the concentration of 12 mg L^-1 of titanium dioxide nanoparticles had the highest effect on increasing the yield of strawberry cv. Sabrina under deficient fertigation.